The RLS Foundation is currently accepting Letters of Intent through our Research Grant Program for projects that promote research to better understand the disease. The deadline for LOI submission is January 23, 2026. Once the review process is complete, projects with potential will be asked to submit a full application. Please click here for RLS Foundation Research Grant Policies and Application Procedures. We appreciate all of the interest and look forward to learning more about these projects.

The primary research priorities for 2026 are:

• Iron homeostasis: - e.g.: Elucidate the genetic/epigenetic, developmental and biological factors that contribute to RLS-relevant alterations in the central nervous system.
• Comorbidities: - e.g.: Elucidate the interactions between RLS and comorbid disorders, such as cardiovascular disease and sleep apnea.
• Genetic/epigenetic: e.g.: Elucidate the interactions between RLS-relevant genetic/epigenetic factors or the consequence of these genetic/epigenetic factors on RLS-relevant neurobiological factors.
• Other topics: Other research areas accepted for funding consideration.

Support the Success of the RLS Research Grant Program

Thanks to generous donations from individuals in the RLS community, the Foundation has funded over $2 million in competitive research grants for the study of RLS since 1997. Every donation makes a real difference in our understanding of the disease, leading us one step closer to a cure. Consider making a donation to the RLS Foundation research program today!

Please read about our most recent grantees and all the exciting research that supporters like you have made possible! We THANK YOU!